About

Howie Seay

Good data is still harder to get than it should be. I build the instruments and software that close the gap between the question and an answer: flow cytometry, spectral analysis, and automated cell therapy manufacturing. Underneath all three it is the same job — work out what people actually need, make the case for building it, and see it through to something they can use. Consulting work runs through How We See LLC.

01 / Focus

What I work on

Three threads, one idea: measurement you can trust, at the scale medicine needs.

Cell therapy manufacturing

Making the automated line real

Product for the Cell Shuttle at Cellares: orchestration, scheduling, reagent and information management, led across five scrum teams and more than 30 developers during the build. That includes the traceability that lets the platform make real patient doses under FDA-regulated quality systems.

Cytometry & spectral

Fifteen years on the instruments

Conventional and full spectral, panel design, cell sorting, and the troubleshooting that keeps a core running. Named inventor on a granted method for modeling and minimizing spillover spreading, and board certified as a Specialist in Cytometry.

Science into software

Requirements from the bench, not the boardroom

Gathered face to face with the scientists who use the thing, at the booth, on site, in the lab. Then come the business cases, pricing, and roadmaps that survive contact with reality.

02 / Hands on

What I build myself

Product leadership is most of the job. This is the other part, and it is the reason I can tell when an estimate is wrong.

Websites

Built and delivered, end to end

This site is mine: Astro, deployed on Vercel from GitHub, with a members area behind a Google sign-in and a private document store on Vercel Blob. The Siskiyou Singers site runs on Neon Postgres. Design, schema, build, deploy.

Algorithms

The math, not a wrapper around it

panel-qc computes a spillover spread matrix from single stains and works out which markers need an FMO. Run against a nine-color human T-cell panel, it found that panel's real design flaw on its own: two PE tandems spreading into each other an order of magnitude above anything else in the matrix. My granted patent is a method for modeling and minimizing the same effect.

Automated testing

Proof the thing does what it says

panel-qc carries 45 passing tests, including a synthetic round trip that plants known coefficients and checks that they come back. At Cellares I built the tool that proves the software meets specification, which replaced a commercial product the company was paying for.

03 / Record

The long version

Fifteen years of it: fee-for-service cytometry and sorting cores at the University of Florida, panel design and spectral unmixing at BD and FlowJo, a genomics platform at Rosalind, and now automated cell therapy manufacturing at Cellares. Two granted patents, a stack of publications, and a peer review habit.

04 / Resources

Flow cytometry, mapped

A curated guide to the field: the communities worth joining, the books worth reading, the software worth learning, and the courses worth the time. Everything I wish someone had handed me on day one.

Browse the resources

05 / Elsewhere

Get SH*t Done

GS*D helps small businesses grow, with skill-building workshops for the DIY-inclined and full project management for anyone ready to hand it off. Consultation, education, facilitation. Run by Danielle Seay.

Get serviced
Get SH*t Done — consultation, education, facilitation

06 / Projects

Things built to settle an argument

Side projects tend to start as a question nobody could answer at the table. The Euchre odds simulator runs Monte Carlo trials across your hand, seat, and the upcard to work out whether calling is the right move, then shows its reasoning.

Run the numbers

07 / Contact

Let's talk

Flow cytometry, product work in life sciences, or something else entirely. Email reaches me directly; LinkedIn works too.